MolNFT v1 · #84218 · protein
Crystal structure of basic patch mutant fak ferm domain FAK31-405 K216A, K218A, R221A, K222A
3ZDT · Focal adhesion kinase 1: “Crystal structure of basic patch mutant fak ferm domain FAK31-405 K216A, K218A, R221A, K222A”. X-ray diffraction, 9 pockets (best druggability 0.76). MolNFT v1 #84218 on GenesisL1: 3D structure, binding…
- PDB
- 3ZDT
- Type
- protein
- Length
- 643 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q00944
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 326 | 40% helix, 24% strand | Q00944 |
| B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 317 | 43% helix, 23% strand | Q00944 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.76 | 0.79 | 79 | empty |
| 2 | 539 | 0.68 | 0.78 | 57 | empty |
| 3 | 166 | 0.59 | 0.82 | 28 | empty |
| 4 | 242 | 0.55 | 0.78 | 30 | empty |
| 5 | 97 | 0.53 | 0.83 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 410 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3ZDT · Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A… · the same entry in another collection · chain A against A, TM-score 1.00
- Q00944 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q00944) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00944
- Elsewhere: RCSB PDB 3ZDT · PDBe 3ZDT · UniProt Q00944
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.