MolNFT v1 · #84092 · protein
Michaelis-like initial complex of camp-dependent protein kinase catalytic subunit.
3X2U · Camp-dependent protein kinase catalytic subunit alpha: “Michaelis-like initial complex of camp-dependent protein kinase catalytic subunit.”. X-ray diffraction, 2 ligands (ATP, MG), 5 pockets (best druggability 0.77). MolNFT v1…
- PDB
- 3X2U
- Type
- protein
- Length
- 359 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase catalytic subunit alpha; Substrate peptide
- EC
- 2.7.11.11
- UniProt
- P05132
- Ligands
- ATP, MG
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11) | protein | 339 | 37% helix, 16% strand | P05132 |
| S | Substrate peptide | protein | 20 | 30% helix, 10% strand | — |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A, S
- MG · Magnesium ion · metal · 2 copies · chains A, S
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.77 | 0.88 | 39 | ATP, MG |
| 2 | 103 | 0.50 | 0.81 | 15 | empty |
| 3 | 76 | 0.47 | 0.82 | 16 | empty |
| 4 | 118 | 0.35 | 0.72 | 19 | empty |
| 5 | 62 | 0.30 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–S · 999 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 3X2U · Michaelis-like initial complex of cAMP-dependent Protein Kinase Catalytic Subunit. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05132
- Elsewhere: RCSB PDB 3X2U · PDBe 3X2U · UniProt P05132
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