MolNFT v1 · #84003 · protein
Crystal structure of PIP4KIIBETA
3WZZ · Phosphatidylinositol 5-phosphate 4-kinase type-2 beta: “Crystal structure of PIP4KIIBETA”. X-ray diffraction, 6 pockets (best druggability 0.66). MolNFT v1 #84003 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3WZZ
- Type
- protein
- Length
- 628 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- EC
- 2.7.1.149
- UniProt
- P78356
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) | protein | 322 | 38% helix, 23% strand | P78356 |
| B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) | protein | 306 | 36% helix, 23% strand | P78356 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 367 | 0.66 | 0.80 | 45 | empty |
| 2 | 370 | 0.65 | 0.79 | 46 | empty |
| 3 | 447 | 0.64 | 0.77 | 74 | empty |
| 4 | 130 | 0.47 | 0.78 | 23 | empty |
| 5 | 79 | 0.34 | 0.75 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1517 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78356
- Elsewhere: RCSB PDB 3WZZ · PDBe 3WZZ · UniProt P78356
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