MolNFT v1 · #83810 · protein
Crystal structure of ets-1 DNA binding and autoinhibitory domains (276-441)
3WTZ · Protein C-ets-1: “Crystal structure of ets-1 DNA binding and autoinhibitory domains (276-441)”. X-ray diffraction, 1 pocket (best druggability 0.28). MolNFT v1 #83810 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3WTZ
- Type
- protein
- Length
- 271 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein C-ets-1
- UniProt
- P14921
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein C-ets-1 | protein | 135 | 47% helix, 10% strand | P14921 |
| B | Protein C-ets-1 | protein | 136 | 47% helix, 10% strand | P14921 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.28 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 728 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3WTZ · Crystal structure of ETS-1 DNA binding and autoinhibitory domains (276-441) · the same entry in another collection · chain A against A, TM-score 1.00
- P14921 · AlphaFold monomer V2.0 prediction for protein C-ets-1 (P14921) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14921
- Elsewhere: RCSB PDB 3WTZ · PDBe 3WTZ · UniProt P14921
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