MolNFT v1 · #8349 · protein
N77Y point mutant of S.CEREVISIAE NTF2
1GY7 · Nuclear transport factor 2: “N77Y point mutant of S.CEREVISIAE NTF2”. X-ray diffraction, 3 pockets (best druggability 0.54). MolNFT v1 #8349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1GY7
- Type
- protein
- Length
- 482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear transport factor 2
- UniProt
- P33331
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 28% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear transport factor 2 | protein | 121 | 30% helix, 50% strand | P33331 |
| B | Nuclear transport factor 2 | protein | 122 | 30% helix, 48% strand | P33331 |
| C | Nuclear transport factor 2 | protein | 119 | 27% helix, 50% strand | P33331 |
| D | Nuclear transport factor 2 | protein | 120 | 28% helix, 49% strand | P33331 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.54 | 0.80 | 31 | empty |
| 2 | 75 | 0.51 | 0.85 | 23 | empty |
| 3 | 72 | 0.29 | 0.73 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1222 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 1146 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 686 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33331
- Elsewhere: RCSB PDB 1GY7 · PDBe 1GY7 · UniProt P33331
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