Research workbench

N77Y point mutant of S.CEREVISIAE NTF2

Analyse N77Y point mutant of S.CEREVISIAE NTF2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1GY7
Type: protein
Length: 482 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear transport factor 2
UniProt: P33331
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 4 distinct chains · 28% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear transport factor 2	protein	121	30% helix, 50% strand	P33331
B	Nuclear transport factor 2	protein	122	30% helix, 48% strand	P33331
C	Nuclear transport factor 2	protein	119	27% helix, 50% strand	P33331
D	Nuclear transport factor 2	protein	120	28% helix, 49% strand	P33331

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	158	0.54	0.80	31	empty
2	75	0.51	0.85	23	empty
3	72	0.29	0.73	15	empty

Interfaces

3 interfaces between chains.

A–B · 1222 Å² buried · 23 hydrogen bonds · protein-protein
C–D · 1146 Å² buried · 19 hydrogen bonds · protein-protein
B–D · 686 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1GY7 · N77Y point mutant of S.Cerevisiae NTF2 · the same entry in another collection · chain D against D, TM-score 1.00
P33331 · AlphaFold monomer V2.0 prediction for nuclear transport factor 2 (P33331) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33331
Elsewhere: RCSB PDB 1GY7 · PDBe 1GY7 · UniProt P33331

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.