MolNFT v1 · #8277 · protein
Structure of leukotriene A4 hydrolase D375N mutant
1GW6 · Leukotriene a-4 hydrolase: “Structure of leukotriene A4 hydrolase D375N mutant”. X-ray diffraction, 3 ligands (BES, YB, ZN), 5 pockets (best druggability 0.86). MolNFT v1 #8277 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1GW6
- Type
- protein
- Length
- 610 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukotriene a-4 hydrolase
- EC
- 3.3.2.6
- UniProt
- P09960
- Ligands
- BES, YB, ZN
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukotriene a-4 hydrolase (EC 3.3.2.6) | protein | 610 | 43% helix, 23% strand | P09960 |
Ligands and binding sites
- BES · 2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid · ligand · chains A
- YB · Ytterbium (III) ion · metal · chains A
- ZN · Zinc ion · metal · chains A
- ACT · Acetate ion · additive · chains A
- IMD · Imidazole · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1048 | 0.86 | 0.87 | 86 | BES, ACT, IMD |
| 2 | 94 | 0.52 | 0.83 | 18 | empty |
| 3 | 207 | 0.52 | 0.77 | 28 | empty |
| 4 | 70 | 0.33 | 0.76 | 13 | empty |
| 5 | 59 | 0.27 | 0.74 | 19 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09960
- Elsewhere: RCSB PDB 1GW6 · PDBe 1GW6 · UniProt P09960
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