MolNFT v1 · #82764 · protein
Crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus
3VWV · Peroxiredoxin-4: “Crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #82764 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3VWV
- Type
- protein
- Length
- 365 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin-4
- EC
- 1.11.1.15
- UniProt
- O08807
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 182 | 29% helix, 27% strand | O08807 |
| B | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 183 | 28% helix, 27% strand | O08807 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.73 | 0.99 | 22 | empty |
| 2 | 93 | 0.61 | 0.88 | 26 | empty |
| 3 | 53 | 0.43 | 0.83 | 22 | empty |
| 4 | 65 | 0.43 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 2398 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3VWV · crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus · the same entry in another collection · chain A against A, TM-score 1.00
- O08807 · AlphaFold monomer V2.0 prediction for peroxiredoxin-4 (O08807) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08807
- Elsewhere: RCSB PDB 3VWV · PDBe 3VWV · UniProt O08807
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.