MolNFT v1 · #8257 · protein

Human prokallikrein 6 (HK6)/ prozyme/ proprotease M/ proneurosin

1GVL: “Human prokallikrein 6 (HK6)/ prozyme/ proprotease M/ proneurosin”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #8257 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1GVL
Type: protein
Length: 223 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kallikrein 6
UniProt: Q92876
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kallikrein 6	protein	223	12% helix, 38% strand	Q92876

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.34	0.77	18	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1GVL · Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin · the same entry in another collection · chain A against A, TM-score 1.00
Q92876 · AlphaFold monomer V2.0 prediction for kallikrein-6 (Q92876) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92876
Elsewhere: RCSB PDB 1GVL · PDBe 1GVL · UniProt Q92876

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