MolNFT v1 · #82322 · protein

Crystal structure of the human squalene synthase

3VJ8: “Crystal structure of the human squalene synthase”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #82322 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3VJ8
Type: protein
Length: 335 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Squalene synthase
EC: 2.5.1.21
UniProt: P37268
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Squalene synthase (EC 2.5.1.21)	protein	335	74% helix, 0% strand	P37268

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	912	0.76	0.79	55	empty
2	86	0.42	0.79	18	empty

Compared structures

3VJ8 · Crystal structure of the human squalene synthase · the same entry in another collection · chain A against A, TM-score 1.00
P37268 · AlphaFold monomer V2.0 prediction for squalene synthase (P37268) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37268
Elsewhere: RCSB PDB 3VJ8 · PDBe 3VJ8 · UniProt P37268

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