UniProt P37268
Squalene synthase (P37268)
Squalene synthase (UniProt P37268), EC 2.5.1.21: 53 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P37268
- Protein
- Squalene synthase
- EC
- 2.5.1.21
- Experimental structures
- 53
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 1 · 1 record with a druggable one
Structures
54 records of P37268 in the MolNFT archive: 53 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EZF | Crystal structure of human squalene synthase | x-ray diffraction | A, B, C | — | — |
| 1EZF | Crystal structure of human squalene synthase | x-ray diffraction | A, B, C | — | — |
| 3ASX | Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2… | x-ray diffraction | A | — | — |
| 3ASX | Human squalene synthase in complex with 1-{4-[{4-chloro-2-[(2… | x-ray diffraction | A | — | — |
| 3LEE | Crystal structure of the human squalene synthase complexed with BPH-652 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3LEE | Crystal structure of the human squalene synthase complexed with bph- 652 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3Q2Z | Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-ox… | x-ray diffraction | A | — | — |
| 3Q2Z | Human squalene synthase in complex with N-[(3R,5S)-7-chloro-5-(2,3… | x-ray diffraction | A | — | — |
| 3Q30 | Human Squalene synthase in complex with (2R,3R)-2-Carboxymethoxy-3-[5-(2-naphthalenyl)pentyl]aminoca… | x-ray diffraction | A | — | — |
| 3Q30 | Human squalene synthase in complex with (2R,3R)-2-carboxymethoxy-3-[5… | x-ray diffraction | A | — | — |
| 3V66 | HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrr… | x-ray diffraction | A | — | — |
| 3V66 | Human squalene synthase in complex with 2-(1-{2-[(4R,6S)-8-chloro-6… | x-ray diffraction | A | — | — |
| 3VJ8 | Crystal structure of the human squalene synthase | x-ray diffraction | A | — | — |
| 3VJ8 | Crystal structure of the human squalene synthase | x-ray diffraction | A | — | — |
| 3VJ9 | Crystal structure of the human squalene synthase | x-ray diffraction | A | — | — |
| 3VJ9 | Crystal structure of the human squalene synthase | x-ray diffraction | A | — | — |
| 3VJA | Crystal structure of the human squalene synthase | x-ray diffraction | A, B | — | — |
| 3VJA | Crystal structure of the human squalene synthase | x-ray diffraction | A, B | — | — |
| 3VJB | Crystal structure of the human squalene synthase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3VJB | Crystal structure of the human squalene synthase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3VJC | Crystal structure of the human squalene synthase in complex with zaragozic acid A | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3VJC | Crystal structure of the human squalene synthase in complex with zaragozic acid a | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WC9 | The complex structure of HsSQS wtih ligand, FSPP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WC9 | The complex structure of hssqs wtih ligand, fspp | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCD | The complex structure of HsSQS wtih ligand, WC-9 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCD | The complex structure of hssqs wtih ligand, wc-9 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCF | The complex structure of HsSQS wtih ligand,BPH1218 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCF | The complex structure of hssqs wtih LIGAND,BPH1218 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCH | The complex structure of HsSQS wtih ligand BPH1237 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCH | The complex structure of hssqs wtih ligand BPH1237 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCI | The complex structure of HsSQS wtih ligand,BPH1325 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCI | The complex structure of hssqs wtih LIGAND,BPH1325 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCJ | The complex structure of HsSQS wtih ligand,E5700 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCJ | The complex structure of hssqs wtih LIGAND,E5700 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCL | The complex structure of HsSQS wtih ligand,BPH1344 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCL | The complex structure of hssqs wtih LIGAND,BPH1344 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCM | The complex structure of HsSQS wtih ligand, ER119884 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WCM | The complex structure of hssqs wtih ligand, ER119884 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WEF | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WEF | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WEG | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and… | x-ray diffraction | A | — | — |
| 3WEG | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and… | x-ray diffraction | A | — | — |
| 3WEH | Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate | x-ray diffraction | A | — | — |
| 3WEH | Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate | x-ray diffraction | A | — | — |
| 3WEI | Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WEI | Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WEJ | Crystal structure of the human squalene synthase F288A mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WEJ | Crystal structure of the human squalene synthase F288A mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WEK | Crystal structure of the human squalene synthase F288L mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WEK | Crystal structure of the human squalene synthase F288L mutant in complex with presqualene… | x-ray diffraction | A | — | — |
| 3WSA | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3WSA | The tuberculosis drug SQ109 inhibits trypanosoma cruzi cell proliferation and acts synergistically… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8WTQ | HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6… | x-ray diffraction | A | PO4, KUO | 1 (best 0.78) |
| P37268 | AlphaFold monomer V2.0 prediction for squalene synthase (P37268) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3WEH chain A against the predicted model P37268: TM-score 0.99, RMSD 0.50 Å
- 3WEH chain A against the predicted model P37268: TM-score 0.99, RMSD 0.50 Å
- 3Q30 chain A against the predicted model P37268: TM-score 0.99, RMSD 0.50 Å
- 3Q30 chain A against the predicted model P37268: TM-score 0.99, RMSD 0.50 Å
- 3WEJ chain A against the predicted model P37268: TM-score 0.99, RMSD 0.56 Å
- 3WEJ chain A against the predicted model P37268: TM-score 0.99, RMSD 0.56 Å
- 3LEE chain C against the predicted model P37268: TM-score 0.99, RMSD 0.58 Å
- 3LEE chain C against the predicted model P37268: TM-score 0.99, RMSD 0.58 Å
- 3LEE chain A against the predicted model P37268: TM-score 0.99, RMSD 0.61 Å
- 3LEE chain A against the predicted model P37268: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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