MolNFT v1 · #8181 · protein

Northeast structural genomics consortium (nesg id TT50) structure of MTH169, the purs subunit of fgam synthetase

1GTD: “Northeast structural genomics consortium (nesg id TT50) structure of MTH169, the purs subunit of fgam…”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #8181 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1GTD
Type: protein
Length: 165 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MTH169
UniProt: O26271
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MTH169	protein	81	36% helix, 38% strand	O26271
B	MTH169	protein	84	35% helix, 39% strand	O26271

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.29	0.74	13	empty
2	51	0.28	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1248 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

1GTD · Northeast structural genomics consortium (nesg id TT50) structure of MTH169, the purs… · the same entry in another collection · chain A against A, TM-score 1.00
O26271 · AlphaFold monomer V2.0 prediction for phosphoribosylformylglycinamidine synthase subunit… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O26271
Elsewhere: RCSB PDB 1GTD · PDBe 1GTD · UniProt O26271

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.