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Northeast structural genomics consortium (nesg id TT50) structure of MTH169, the purs subunit of fgam synthetase

Analyse Northeast structural genomics consortium (nesg id TT50) structure of MTH169… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1GTD
Type: protein
Length: 165 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MTH169
UniProt: O26271
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MTH169	protein	81	36% helix, 38% strand	O26271
B	MTH169	protein	84	35% helix, 39% strand	O26271

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.29	0.74	13	empty
2	51	0.28	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1248 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

1GTD · Northeast structural genomics consortium (nesg id TT50) structure of MTH169, the purs… · the same entry in another collection · chain A against A, TM-score 1.00
O26271 · AlphaFold monomer V2.0 prediction for phosphoribosylformylglycinamidine synthase subunit… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O26271
Elsewhere: RCSB PDB 1GTD · PDBe 1GTD · UniProt O26271

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