MolNFT v1 · #81580 · protein
Crystal structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with N-methyl-2-pyrrolidone
3UVD: “Crystal structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with…”. X-ray diffraction, 1 ligand (MB3), 1 pocket (best druggability 0.43). MolNFT v1 #81580 on GenesisL1: 3D structure, binding sites…
- PDB
- 3UVD
- Type
- protein
- Length
- 122 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription activator BRG1
- EC
- 3.6.4.-
- UniProt
- P51532
- Ligands
- MB3
- Pockets
- 1 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription activator BRG1 (EC 3.6.4.-) | protein | 122 | 62% helix, 2% strand | P51532 |
Ligands and binding sites
- MB3 · 1-methylpyrrolidin-2-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.43 | 0.81 | 15 | MB3 |
Compared structures
- 3UVD · Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in… · the same entry in another collection · chain A against A, TM-score 1.00
- P51532 · AlphaFold monomer V2.0 prediction for transcription activator BRG1 (P51532) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51532
- Elsewhere: RCSB PDB 3UVD · PDBe 3UVD · UniProt P51532
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