MolNFT v1 · #81567 · protein
Crystal structure of yeast FIS1 in complex with MDV1 fragment containing N-terminal extension and coiled coil domains
3UUX · Mitochondria fission 1 protein: “Crystal structure of yeast FIS1 in complex with MDV1 fragment containing N-terminal extension and coiled coil…”. X-ray diffraction, 4 pockets (best druggability 0.72). MolNFT v1 #81567 on GenesisL1…
- PDB
- 3UUX
- Type
- protein
- Length
- 519 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondria fission 1 protein; Mitochondrial division protein 1
- UniProt
- P40515, P47025
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondria fission 1 protein | protein | 127 | 77% helix, 0% strand | P40515 |
| B | Mitochondrial division protein 1 | protein | 132 | 79% helix, 0% strand | P47025 |
| C | Mitochondria fission 1 protein | protein | 125 | 78% helix, 0% strand | P40515 |
| D | Mitochondrial division protein 1 | protein | 135 | 67% helix, 0% strand | P47025 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 834 | 0.72 | 0.77 | 51 | empty |
| 2 | 102 | 0.38 | 0.75 | 19 | empty |
| 3 | 85 | 0.33 | 0.74 | 17 | empty |
| 4 | 50 | 0.26 | 0.74 | 13 | empty |
Interfaces
4 interfaces between chains.
- C–D · 2046 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1882 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 241 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 120 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3UUX · Crystal structure of yeast Fis1 in complex with Mdv1 fragment containing N-terminal… · the same entry in another collection · chain D against D, TM-score 1.00
- P40515 · AlphaFold monomer V2.0 prediction for mitochondrial fission 1 protein (P40515) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P47025 · AlphaFold monomer V2.0 prediction for mitochondrial division protein 1 (P47025) · a predicted model of the same protein · chain B against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40515
- Every structure of UniProt P47025
- Elsewhere: RCSB PDB 3UUX · PDBe 3UUX · UniProt P40515 · UniProt P47025
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