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Crystal structure of yeast FIS1 in complex with MDV1 fragment containing N-terminal extension and coiled coil domains

Analyse Crystal structure of yeast FIS1 in complex with MDV1 fragment containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3UUX
Type: protein
Length: 519 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondria fission 1 protein; Mitochondrial division protein 1
UniProt: P40515, P47025
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitochondria fission 1 protein	protein	127	77% helix, 0% strand	P40515
B	Mitochondrial division protein 1	protein	132	79% helix, 0% strand	P47025
C	Mitochondria fission 1 protein	protein	125	78% helix, 0% strand	P40515
D	Mitochondrial division protein 1	protein	135	67% helix, 0% strand	P47025

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	834	0.72	0.77	51	empty
2	102	0.38	0.75	19	empty
3	85	0.33	0.74	17	empty
4	50	0.26	0.74	13	empty

Interfaces

4 interfaces between chains.

C–D · 2046 Å² buried · 27 hydrogen bonds · protein-protein
A–B · 1882 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 241 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 120 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3UUX · Crystal structure of yeast Fis1 in complex with Mdv1 fragment containing N-terminal… · the same entry in another collection · chain D against D, TM-score 1.00
P40515 · AlphaFold monomer V2.0 prediction for mitochondrial fission 1 protein (P40515) · a predicted model of the same protein · chain A against A, TM-score 0.96
P47025 · AlphaFold monomer V2.0 prediction for mitochondrial division protein 1 (P47025) · a predicted model of the same protein · chain B against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40515
Every structure of UniProt P47025
Elsewhere: RCSB PDB 3UUX · PDBe 3UUX · UniProt P40515 · UniProt P47025

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