MolNFT v1 · #81547 · protein
The glic pentameric ligand-gated ion channel LOOP2-20' oxidized mutant in a locally-closed conformation (LC1 subtype)
3UU3 · GLR4197 protein: “The glic pentameric ligand-gated ion channel LOOP2-20' oxidized mutant in a locally-closed conformation (LC1…”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #81547 on GenesisL1: 3D structure…
- PDB
- 3UU3
- Type
- protein
- Length
- 1,527 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLR4197 protein
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E | GLR4197 protein | protein | 305 | 38% helix, 33% strand | Q7NDN8 |
| C, D | GLR4197 protein | protein | 306 | 38% helix, 32% strand | Q7NDN8 |
Ligands and binding sites
- LMT · Dodecyl-beta-D-maltoside · additive · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 411 | 0.84 | 0.92 | 48 | LMT |
| 2 | 629 | 0.79 | 0.84 | 59 | empty |
| 3 | 605 | 0.79 | 0.84 | 60 | empty |
| 4 | 685 | 0.78 | 0.83 | 62 | empty |
| 5 | 651 | 0.78 | 0.83 | 63 | empty |
Interfaces
8 interfaces between chains.
- B–C · 2278 Ų buried · 20 hydrogen bonds · protein-protein
- A–E · 2235 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 2205 Ų buried · 22 hydrogen bonds · protein-protein
- D–E · 2196 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 2193 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 3UU3 · The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3UU3 · PDBe 3UU3 · UniProt Q7NDN8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.