MolNFT v1 · #81450 · protein

Structure of the CMR2 subunit of the CRISPR RNA silencing complex

3UR3 · CMR2DHD: “Structure of the CMR2 subunit of the CRISPR RNA silencing complex”. X-ray diffraction, 2 ligands (CA, ZN), 6 pockets (best druggability 0.67). MolNFT v1 #81450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UR3
Type: protein
Length: 548 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CMR2DHD
UniProt: Q8U1S6
Ligands: CA, ZN
Pockets: 6 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	CMR2DHD	protein	548	55% helix, 15% strand	Q8U1S6

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains C
ZN · Zinc ion · metal · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	537	0.67	0.77	47	CA
2	85	0.67	0.92	17	empty
3	203	0.57	0.79	27	empty
4	367	0.56	0.74	41	empty
5	78	0.38	0.77	15	empty

Compared structures

3UR3 · Structure of the Cmr2 subunit of the CRISPR RNA silencing complex · the same entry in another collection · chain C against C, TM-score 1.00
Q8U1S6 · AlphaFold monomer V2.0 prediction for CRISPR system cmr subunit CMR2 (Q8U1S6) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8U1S6
Elsewhere: RCSB PDB 3UR3 · PDBe 3UR3 · UniProt Q8U1S6

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