MolNFT v1 · #81377 · protein

Crystal structure of otemo (FAD bound form 1)

3UOV: “Crystal structure of otemo (FAD bound form 1)”. X-ray diffraction, 1 ligand (FAD), 9 pockets (best druggability 0.85). MolNFT v1 #81377 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UOV
Type: protein
Length: 1,071 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Otemo
EC: 1.-.-.-
Ligands: FAD
Pockets: 9 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Otemo (EC 1.-.-.-)	protein	536	36% helix, 20% strand	—
B	Otemo (EC 1.-.-.-)	protein	535	37% helix, 20% strand	—

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1133	0.85	0.86	105	FAD
2	1082	0.85	0.85	97	FAD
3	1140	0.84	0.84	122	empty
4	206	0.51	0.77	39	empty
5	88	0.34	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 1132 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3UOV · Crystal Structure of OTEMO (FAD bound form 1) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3UOV · PDBe 3UOV

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