MolNFT v1 · #81337 · protein
Crystal structure of the human MDC1 fha domain
3UNM · Mediator of DNA damage checkpoint protein 1: “Crystal structure of the human MDC1 fha domain”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #81337 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3UNM
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mediator of DNA damage checkpoint protein 1
- UniProt
- Q14676
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mediator of DNA damage checkpoint protein 1 | protein | 101 | 0% helix, 47% strand | Q14676 |
| B | Mediator of DNA damage checkpoint protein 1 | protein | 106 | 0% helix, 46% strand | Q14676 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.55 | 0.80 | 18 | empty |
| 2 | 89 | 0.36 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 412 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3UNM · Crystal Structure of The Human MDC1 FHA Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q14676 · AlphaFold monomer V2.0 prediction for mediator of DNA damage checkpoint protein 1 (Q14676) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14676
- Elsewhere: RCSB PDB 3UNM · PDBe 3UNM · UniProt Q14676
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