MolNFT v1 · #81331 · protein
Structure of the CMR2 subunit of the CRISPR RNA silencing complex
3UNG · CMR2DHD: “Structure of the CMR2 subunit of the CRISPR RNA silencing complex”. X-ray diffraction, 3 ligands (ADP, CA, ZN), 7 pockets (best druggability 0.63). MolNFT v1 #81331 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3UNG
- Type
- protein
- Length
- 548 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CMR2DHD
- UniProt
- Q8U1S6
- Ligands
- ADP, CA, ZN
- Pockets
- 7 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | CMR2DHD | protein | 548 | 57% helix, 14% strand | Q8U1S6 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains C
- CA · Calcium ion · metal · 2 copies · chains C
- ZN · Zinc ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.63 | 0.78 | 42 | CA, ADP |
| 2 | 258 | 0.58 | 0.78 | 25 | empty |
| 3 | 93 | 0.56 | 0.85 | 15 | empty |
| 4 | 65 | 0.44 | 0.82 | 11 | empty |
| 5 | 112 | 0.37 | 0.74 | 17 | empty |
Compared structures
- 3UNG · Structure of the Cmr2 subunit of the CRISPR RNA silencing complex · the same entry in another collection · chain C against C, TM-score 1.00
- Q8U1S6 · AlphaFold monomer V2.0 prediction for CRISPR system cmr subunit CMR2 (Q8U1S6) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U1S6
- Elsewhere: RCSB PDB 3UNG · PDBe 3UNG · UniProt Q8U1S6
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