MolNFT v1 · #8122 · protein

GRB2

1GRI · Growth factor bound protein 2: “GRB2”. X-ray diffraction, 7 pockets (best druggability 0.83). MolNFT v1 #8122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1GRI
Type: protein
Length: 422 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Growth factor bound protein 2
UniProt: P62993
Pockets: 7 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Growth factor bound protein 2	protein	211	12% helix, 35% strand	P62993

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.83	0.96	42	empty
2	105	0.62	0.88	20	empty
3	100	0.59	0.87	21	empty
4	155	0.45	0.76	20	empty
5	148	0.44	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 2528 Å² buried · 50 hydrogen bonds · protein-protein

Compared structures

1GRI · GRB2 · the same entry in another collection · chain A against A, TM-score 1.00
P62993 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (P62993) · a predicted model of the same protein · chain A against A, TM-score 0.46

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62993
Elsewhere: RCSB PDB 1GRI · PDBe 1GRI · UniProt P62993

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