MolNFT v1 · #81050 · protein
Crystal structure of the mouse colony-stimulating factor 1 (mcsf-1) cytokine
3UF5 · Macrophage colony-stimulating factor 1: “Crystal structure of the mouse colony-stimulating factor 1 (mcsf-1) cytokine”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.36). MolNFT v1 #81050 on GenesisL1: 3D…
- PDB
- 3UF5
- Type
- protein
- Length
- 289 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage colony-stimulating factor 1
- UniProt
- P07141
- Ligands
- CA
- Pockets
- 3 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage colony-stimulating factor 1 | protein | 145 | 57% helix, 9% strand | P07141 |
| B | Macrophage colony-stimulating factor 1 | protein | 144 | 60% helix, 9% strand | P07141 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.36 | 0.78 | 12 | empty |
| 2 | 56 | 0.27 | 0.73 | 19 | empty |
| 3 | 57 | 0.26 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 849 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3UF5 · Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine · the same entry in another collection · chain A against A, TM-score 1.00
- P07141 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 (P07141) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07141
- Elsewhere: RCSB PDB 3UF5 · PDBe 3UF5 · UniProt P07141
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.