MolNFT v1 · #80572 · protein
Ad related murine antibody fragment
3U0W · Fab heavy chain, ig gamma-1 chain C region: “Ad related murine antibody fragment”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #80572 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3U0W
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab heavy chain, ig gamma-1 chain C region; Fab light chain, ig kappa chain C region
- UniProt
- P01857, P01834
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab heavy chain, ig gamma-1 chain C region | protein | 206 | 11% helix, 51% strand | P01857 |
| L | Fab light chain, ig kappa chain C region | protein | 213 | 6% helix, 50% strand | P01834 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.50 | 0.75 | 43 | empty |
| 2 | 96 | 0.39 | 0.76 | 14 | empty |
| 3 | 90 | 0.34 | 0.74 | 19 | empty |
| 4 | 50 | 0.28 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- H–L · 1547 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01857
- Every structure of UniProt P01834
- Elsewhere: RCSB PDB 3U0W · PDBe 3U0W · UniProt P01857 · UniProt P01834
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