MolNFT v1 · #8016 · protein
Monitoring the structural consequences of PHE12-->D-PHE12 and LEU15-->AIB15 substitution in H/R corticotropin releasing hormone: implications for design of crh antagonists.
1GO9: “Monitoring the structural consequences of PHE12-->D-PHE12 and LEU15-->AIB15 substitution in H/R corticotropin…”. Solution nmr, 1 ligand (NH2). MolNFT v1 #8016 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1GO9
- Type
- protein
- Length
- 41 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Corticotropin releasing hormone
- UniProt
- P06850
- Ligands
- NH2
Structure
solution nmr · 1 distinct chain · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Corticotropin releasing hormone | protein | 41 | 83% helix, 0% strand | P06850 |
Ligands and binding sites
- NH2 · Amino group · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 1 d-amino, 1 modified (D-amino acid, nonstandard).
Compared structures
- 1GO9 · Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution… · the same entry in another collection · chain A against A, TM-score 1.00
- P06850 · AlphaFold monomer V2.0 prediction for corticoliberin (P06850) · a predicted model of the same protein · chain A against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06850
- Elsewhere: RCSB PDB 1GO9 · PDBe 1GO9 · UniProt P06850
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