MolNFT v1 · #80069 · protein
The glic pentameric ligand-gated ion channel H11'F mutant in a locally-closed conformation (LC1 subtype)
3TLT · GLR4197 protein: “The glic pentameric ligand-gated ion channel H11'F mutant in a locally-closed conformation (LC1 subtype)”. X-ray diffraction, 1 ligand (CL), 20 pockets (best druggability 0.84). MolNFT v1 #80069 on GenesisL1: 3D…
- PDB
- 3TLT
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLR4197 protein
- UniProt
- Q7NDN8
- Ligands
- CL
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | GLR4197 protein | protein | 311 | 36% helix, 34% strand | Q7NDN8 |
Ligands and binding sites
- CL · Chloride ion · ion · 5 copies · chains A, B, C, D, E
- LMT · Dodecyl-beta-D-maltoside · additive · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 726 | 0.84 | 0.87 | 82 | empty |
| 2 | 476 | 0.83 | 0.90 | 52 | empty |
| 3 | 1149 | 0.82 | 0.83 | 118 | empty |
| 4 | 202 | 0.81 | 0.95 | 24 | empty |
| 5 | 582 | 0.80 | 0.86 | 59 | LMT |
Interfaces
5 interfaces between chains.
- B–C · 2309 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 2308 Ų buried · 16 hydrogen bonds · protein-protein
- D–E · 2304 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2271 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 2268 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3TLT · The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3TLT · PDBe 3TLT · UniProt Q7NDN8
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