MolNFT v1 · #80057 · protein

Microcin C7 self immunity protein mccf in the inactive mutant apo state

3TLG: “Microcin C7 self immunity protein mccf in the inactive mutant apo state”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #80057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3TLG
Type: protein
Length: 668 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mccf
UniProt: Q2KKH9
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mccf	protein	333	32% helix, 23% strand	Q2KKH9
B	Mccf	protein	335	31% helix, 23% strand	Q2KKH9

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	670	0.68	0.77	82	empty
2	170	0.54	0.79	24	empty
3	96	0.53	0.83	25	empty
4	53	0.30	0.76	11	empty

Interfaces

1 interface between chains.

A–B · 1872 Å² buried · 47 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

3TLG · Microcin C7 self immunity protein MccF in the inactive mutant APO state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2KKH9
Elsewhere: RCSB PDB 3TLG · PDBe 3TLG · UniProt Q2KKH9

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