MolNFT v1 · #80042 · protein

Structure of SHP2 N-SH2 domain in complex with rlnpyaqlwhr peptide

3TL0 · Tyrosine-protein phosphatase non-receptor type 11: “Structure of SHP2 N-SH2 domain in complex with rlnpyaqlwhr peptide”. X-ray diffraction, 1 ligand (SO4). MolNFT v1 #80042 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3TL0
Type: protein
Length: 106 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11; Rlnpyaqlwhr peptide
EC: 3.1.3.48
UniProt: Q06124
Ligands: SO4

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	99	21% helix, 30% strand	Q06124
B	Rlnpyaqlwhr peptide	protein	7	0% helix, 29% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 510 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

3TL0 · Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 3TL0 · PDBe 3TL0 · UniProt Q06124

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