MolNFT v1 · #80021 · protein
Crystal structure of human uracil-DNA glycosylase D183G/K302R mutant
3TKB: “Crystal structure of human uracil-DNA glycosylase D183G/K302R mutant”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #80021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3TKB
- Type
- protein
- Length
- 223 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uracil-DNA glycosylase
- EC
- 3.2.2.27
- UniProt
- P13051
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uracil-DNA glycosylase (EC 3.2.2.27) | protein | 223 | 41% helix, 11% strand | P13051 |
Ligands and binding sites
- IMD · Imidazole · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.51 | 0.80 | 31 | empty |
| 2 | 63 | 0.35 | 0.77 | 13 | empty |
Compared structures
- 3TKB · crystal structure of human uracil-DNA glycosylase D183G/K302R mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P13051 · AlphaFold monomer V2.0 prediction for uracil-DNA glycosylase (P13051) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13051
- Elsewhere: RCSB PDB 3TKB · PDBe 3TKB · UniProt P13051
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