Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (KIR3.2) in complex with sodium and PIP2

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).

Ligands and binding sites

• PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · ligand · chains A
• K · Potassium ion · metal · 5 copies · chains A
• NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 3SYA · Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in… · the same entry in another collection · chain A against A, TM-score 1.00
• P48542 · AlphaFold monomer V2.0 prediction for G protein-activated inward rectifier potassium… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P48542
• Elsewhere: RCSB PDB 3SYA · PDBe 3SYA · UniProt P48542