MolNFT v1 · #78777 · protein
Crystal structure of S.CEREVISIAE GET3 in the semi-open state in complex with GET1 cytosolic domain
3SJC · ATPase GET3: “Crystal structure of S.CEREVISIAE GET3 in the semi-open state in complex with GET1 cytosolic domain”. X-ray diffraction, 1 ligand (ZN), 19 pockets (best druggability 0.88). MolNFT v1 #78777 on GenesisL1: 3D structure…
- PDB
- 3SJC
- Type
- protein
- Length
- 1,324 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATPase GET3; Golgi to er traffic protein 1
- EC
- 3.6.-.-
- UniProt
- Q12154, P53192
- Ligands
- ZN
- Pockets
- 19 · best druggability 0.88
Structure
x-ray diffraction · 5 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATPase GET3 (EC 3.6.-.-) | protein | 276 | 44% helix, 17% strand | Q12154 |
| B | ATPase GET3 (EC 3.6.-.-) | protein | 277 | 45% helix, 17% strand | Q12154 |
| C, D, G, H | Golgi to er traffic protein 1 | protein | 54 | 81% helix, 0% strand | P53192 |
| E | ATPase GET3 (EC 3.6.-.-) | protein | 279 | 45% helix, 16% strand | Q12154 |
| F | ATPase GET3 (EC 3.6.-.-) | protein | 276 | 45% helix, 16% strand | Q12154 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1147 | 0.88 | 0.90 | 106 | empty |
| 2 | 1148 | 0.88 | 0.89 | 109 | empty |
| 3 | 345 | 0.68 | 0.82 | 49 | empty |
| 4 | 253 | 0.68 | 0.84 | 38 | empty |
| 5 | 364 | 0.66 | 0.80 | 49 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1218 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 1206 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 535 Ų buried · 10 hydrogen bonds · protein-protein
- E–H · 535 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 534 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3SJC · Crystal structure of S.cerevisiae Get3 in the semi-open state in complex with Get1… · the same entry in another collection · chain H against H, TM-score 1.00
- P53192 · AlphaFold monomer V2.0 prediction for golgi to er traffic protein 1 (P53192) · a predicted model of the same protein · chain G against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12154
- Every structure of UniProt P53192
- Elsewhere: RCSB PDB 3SJC · PDBe 3SJC · UniProt Q12154 · UniProt P53192
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