MolNFT v1 · #78776 · protein
Crystal structure of S. cerevisiae GET3 in the open state in complex with GET1 cytosolic domain
3SJB · ATPase GET3: “Crystal structure of S. cerevisiae GET3 in the open state in complex with GET1 cytosolic domain”. X-ray diffraction, 2 ligands (ZN, PO4), 8 pockets (best druggability 0.86). MolNFT v1 #78776 on GenesisL1: 3D structure…
- PDB
- 3SJB
- Type
- protein
- Length
- 725 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATPase GET3; Golgi to er traffic protein 1
- EC
- 3.6.-.-
- UniProt
- Q12154, P53192
- Ligands
- ZN, PO4
- Pockets
- 8 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATPase GET3 (EC 3.6.-.-) | protein | 288 | 47% helix, 16% strand | Q12154 |
| B | ATPase GET3 (EC 3.6.-.-) | protein | 302 | 50% helix, 15% strand | Q12154 |
| C | Golgi to er traffic protein 1 | protein | 63 | 84% helix, 0% strand | P53192 |
| D | Golgi to er traffic protein 1 | protein | 72 | 86% helix, 0% strand | P53192 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.86 | 0.87 | 126 | PO4 |
| 2 | 730 | 0.78 | 0.83 | 71 | empty |
| 3 | 139 | 0.71 | 0.91 | 22 | empty |
| 4 | 113 | 0.44 | 0.77 | 17 | empty |
| 5 | 114 | 0.43 | 0.77 | 18 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1063 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 551 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 544 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 523 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 511 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3SJB · Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic… · the same entry in another collection · chain D against D, TM-score 1.00
- P53192 · AlphaFold monomer V2.0 prediction for golgi to er traffic protein 1 (P53192) · a predicted model of the same protein · chain C against A, TM-score 0.97
- Q12154 · AlphaFold monomer V2.0 prediction for ATPase GET3 (Q12154) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12154
- Every structure of UniProt P53192
- Elsewhere: RCSB PDB 3SJB · PDBe 3SJB · UniProt Q12154 · UniProt P53192
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