RUSSELL'S viper venom serine proteinase, rvv-V (ppack-bound form)

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 35% strand (DSSP).

Ligands and binding sites

• 0G6 · D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 6 disulfide, 2 covalent, 1 glycan (disulfide, covalent ligand, N-glycosylation).

Compared structures

• 3SBK · Russell's viper venom serine proteinase, RVV-V (PPACK-bound form) · the same entry in another collection · chain A against A, TM-score 1.00
• P18965 · AlphaFold monomer V2.0 prediction for factor V activator rvv-V gamma (P18965) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P18965
• Elsewhere: RCSB PDB 3SBK · PDBe 3SBK · UniProt P18965