MolNFT v1 · #498440 · protein
AlphaFold monomer V2.0 prediction for factor V activator rvv-V gamma (P18965)
P18965: “AlphaFold monomer V2.0 prediction for factor V activator rvv-V gamma (P18965)”. 2 pockets (best druggability 0.49). MolNFT v1 #498440 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P18965
- Type
- protein
- Length
- 260 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd2B806f92bedc80F03610Bf62FF190193655f360
- Molecule
- Factor V activator rvv-V gamma
- UniProt
- P18965
- Pockets
- 2 · best druggability 0.49
Structure
1 distinct chain · 7% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Factor V activator rvv-V gamma | protein | 260 | 7% helix, 31% strand | P18965 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.49 | 0.82 | 21 | empty |
| 2 | 53 | 0.33 | 0.78 | 16 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3S9C · Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3S9C · RUSSELL'S viper venom serine proteinase, rvv-V in complex with the fragment (residues… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3S9B · RUSSELL'S viper venom serine proteinase, rvv-V (open-form) · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3S9B · Russell's viper venom serine proteinase, RVV-V (open-form) · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 3SBK · RUSSELL'S viper venom serine proteinase, rvv-V (ppack-bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3SBK · Russell's viper venom serine proteinase, RVV-V (PPACK-bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3S9A · RUSSELL'S viper venom serine proteinase, rvv-V (closed-form) · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 3S9A · Russell's viper venom serine proteinase, RVV-V (closed-form) · an experimental structure of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18965
- Elsewhere: UniProt P18965 · AlphaFold DB P18965
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