MolNFT v1 · #78137 · protein
Mouse importin alpha-KU70 nls peptide complex
3RZX · Importin subunit alpha-2: “Mouse importin alpha-KU70 nls peptide complex”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #78137 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3RZX
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-2; KU70 nls peptide
- UniProt
- P52293, P12956
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-2 | protein | 427 | 75% helix, 0% strand | P52293 |
| B | KU70 nls peptide | protein | 12 | 0% helix, 0% strand | P12956 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.45 | 0.82 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 816 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3RZX · Mouse importin alpha-Ku70 NLS peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P12956 · AlphaFold monomer V2.0 prediction for X-ray repair cross- complementing protein 6 (P12956) · a predicted model of the same protein · chain B against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P12956
- Elsewhere: RCSB PDB 3RZX · PDBe 3RZX · UniProt P52293 · UniProt P12956
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