MolNFT v1 · #78015 · protein
Structure of N-terminal domain of nuclear RNA export factor tap
3RW7 · Nuclear RNA export factor 1: “Structure of N-terminal domain of nuclear RNA export factor tap”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #78015 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3RW7
- Type
- protein
- Length
- 803 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear RNA export factor 1
- UniProt
- Q9UBU9
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear RNA export factor 1 | protein | 242 | 31% helix, 18% strand | Q9UBU9 |
| B | Nuclear RNA export factor 1 | protein | 160 | 39% helix, 11% strand | Q9UBU9 |
| C | Nuclear RNA export factor 1 | protein | 242 | 35% helix, 18% strand | Q9UBU9 |
| D | Nuclear RNA export factor 1 | protein | 159 | 38% helix, 11% strand | Q9UBU9 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1006 | 0.80 | 0.81 | 81 | empty |
| 2 | 1199 | 0.79 | 0.81 | 78 | empty |
| 3 | 724 | 0.72 | 0.78 | 85 | empty |
| 4 | 73 | 0.71 | 0.96 | 20 | empty |
| 5 | 152 | 0.50 | 0.79 | 25 | empty |
Interfaces
5 interfaces between chains.
- A–D · 946 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 912 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 730 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 677 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 596 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3RW7 · Structure of N-terminal domain of nuclear RNA export factor TAP · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UBU9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9UBU9) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBU9
- Elsewhere: RCSB PDB 3RW7 · PDBe 3RW7 · UniProt Q9UBU9
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