MolNFT v1 · #77846 · protein

TRNA-guanine transglycosylase in complex with N-methyl-lin- benzoguanine inhibitor

3RR4 · Queuine tRNA-ribosyltransferase: “TRNA-guanine transglycosylase in complex with N-methyl-lin- benzoguanine inhibitor”. X-ray diffraction, 2 ligands (HRD, ZN), 2 pockets (best druggability 0.66). MolNFT v1 #77846 on GenesisL1: 3D…

PDB: 3RR4
Type: protein
Length: 368 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: HRD, ZN
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	368	46% helix, 18% strand	P28720

Ligands and binding sites

HRD · 2,6-bis(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.66	0.86	28	HRD
2	53	0.40	0.81	17	empty

Compared structures

3RR4 · tRNA-Guanine Transglycosylase in complex with N-Methyl-lin-Benzoguanine Inhibitor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 3RR4 · PDBe 3RR4 · UniProt P28720

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