MolNFT v1 · #77706 · protein
Crystal structure of human glycogenin-1 (GYG1) T83M mutant complexed with manganese and udp-glucose
3RMW: “Crystal structure of human glycogenin-1 (GYG1) T83M mutant complexed with manganese and udp-glucose”. X-ray diffraction, 3 ligands (UPG, MN, MG), 2 pockets (best druggability 0.54). MolNFT v1 #77706 on GenesisL1: 3D structure…
- PDB
- 3RMW
- Type
- protein
- Length
- 250 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogenin-1
- EC
- 2.4.1.186
- UniProt
- P46976
- Ligands
- UPG, MN, MG
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogenin-1 (EC 2.4.1.186) | protein | 250 | 42% helix, 20% strand | P46976 |
Ligands and binding sites
- UPG · Uridine-5'-diphosphate-glucose · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
- MG · Magnesium ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 12 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.54 | 0.77 | 26 | UPG, EDO |
| 2 | 64 | 0.31 | 0.74 | 12 | empty |
Compared structures
- 3RMW · Crystal Structure of Human Glycogenin-1 (GYG1) T83M mutant complexed with manganese and… · the same entry in another collection · chain A against A, TM-score 1.00
- P46976 · AlphaFold monomer V2.0 prediction for glycogenin-1 (P46976) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46976
- Elsewhere: RCSB PDB 3RMW · PDBe 3RMW · UniProt P46976
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