Crystal structure of Fc ri and its implication to high affinity immunoglobulin G binding

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 53% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 3 copies
• FUC · alpha-L-fucopyranose · sugar · chains A
• P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 6 glycan, 3 disulfide (N-glycosylation, disulfide).

Compared structures

• 3RJD · Crystal structure of Fc RI and its implication to high affinity immunoglobulin G binding · the same entry in another collection · chain A against A, TM-score 1.00
• P12314 · AlphaFold monomer V2.0 prediction for high affinity immunoglobulin gamma Fc receptor I… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P12314
• Elsewhere: RCSB PDB 3RJD · PDBe 3RJD · UniProt P12314