MolNFT v1 · #77370 · protein

RAD60 SLD2 UBC9 complex

3RCZ · DNA repair protein RAD60: “RAD60 SLD2 UBC9 complex”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #77370 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3RCZ
Type: protein
Length: 229 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA repair protein RAD60; Sumo-conjugating enzyme UBC9
EC: 6.3.2.-
UniProt: Q9USX3, P40984
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA repair protein RAD60	protein	74	20% helix, 35% strand	Q9USX3
B	Sumo-conjugating enzyme UBC9 (EC 6.3.2.-)	protein	155	34% helix, 20% strand	P40984

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.46	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 629 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3RCZ · Rad60 SLD2 Ubc9 Complex · the same entry in another collection · chain A against A, TM-score 1.00
P40984 · AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P40984) · a predicted model of the same protein · chain B against A, TM-score 0.99
Q9USX3 · AlphaFold monomer V2.0 prediction for DNA repair protein RAD60 (Q9USX3) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9USX3
Every structure of UniProt P40984
Elsewhere: RCSB PDB 3RCZ · PDBe 3RCZ · UniProt Q9USX3 · UniProt P40984

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.