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RAD60 SLD2 UBC9 complex

Analyse RAD60 SLD2 UBC9 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3RCZ
Type
protein
Length
229 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA repair protein RAD60; Sumo-conjugating enzyme UBC9
EC
6.3.2.-
UniProt
Q9USX3, P40984
Pockets
1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 25% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA repair protein RAD60protein7420% helix, 35% strandQ9USX3
BSumo-conjugating enzyme UBC9 (EC 6.3.2.-)protein15534% helix, 20% strandP40984

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11400.460.7723empty

Interfaces

1 interface between chains.

  • A–B · 629 Ų buried · 13 hydrogen bonds · protein-protein

Compared structures

  • 3RCZ · Rad60 SLD2 Ubc9 Complex · the same entry in another collection · chain A against A, TM-score 1.00
  • P40984 · AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P40984) · a predicted model of the same protein · chain B against A, TM-score 0.99
  • Q9USX3 · AlphaFold monomer V2.0 prediction for DNA repair protein RAD60 (Q9USX3) · a predicted model of the same protein · chain A against A, TM-score 0.96

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