MolNFT v1 · #77299 · protein
Canine GDP-ran Q69L mutant
3RAN · Protein (GTP-binding nuclear protein ran): “Canine GDP-ran Q69L mutant”. X-ray diffraction, 2 ligands (GDP, MG), 2 pockets (best druggability 0.73). MolNFT v1 #77299 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3RAN
- Type
- protein
- Length
- 811 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (GTP-binding nuclear protein ran)
- UniProt
- P62825
- Ligands
- GDP, MG
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (GTP-binding nuclear protein ran) | protein | 201 | 31% helix, 28% strand | P62825 |
| B | Protein (GTP-binding nuclear protein ran) | protein | 204 | 31% helix, 27% strand | P62825 |
| C, D | Protein (GTP-binding nuclear protein ran) | protein | 203 | 34% helix, 27% strand | P62825 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 856 | 0.73 | 0.78 | 69 | empty |
| 2 | 999 | 0.70 | 0.74 | 76 | empty |
Interfaces
3 interfaces between chains.
- B–D · 342 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 182 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 112 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62825
- Elsewhere: RCSB PDB 3RAN · PDBe 3RAN · UniProt P62825
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