MolNFT v1 · #77195 · protein
Crystal structure of spire kind domain in complex with the tail of FMN2
3R7G · Protein spire homolog 1: “Crystal structure of spire kind domain in complex with the tail of FMN2”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #77195 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3R7G
- Type
- protein
- Length
- 173 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein spire homolog 1; Formin-2
- UniProt
- Q08AE8, Q9NZ56
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein spire homolog 1 | protein | 154 | 57% helix, 8% strand | Q08AE8 |
| B | Formin-2 | protein | 19 | 32% helix, 16% strand | Q9NZ56 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.37 | 0.80 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 925 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 3R7G · Crystal structure of Spire KIND domain in complex with the tail of FMN2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q08AE8 · AlphaFold monomer V2.0 prediction for protein spire homolog 1 (Q08AE8) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9NZ56 · AlphaFold monomer V2.0 prediction for formin-2 (Q9NZ56) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08AE8
- Every structure of UniProt Q9NZ56
- Elsewhere: RCSB PDB 3R7G · PDBe 3R7G · UniProt Q08AE8 · UniProt Q9NZ56
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