MolNFT v1 · #77184 · protein

Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase phze from burkholderia lata 383

3R74 · ANTHRANILATE/PARA-aminobenzoate synthases component I: “Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase phze from burkholderia lata 383”. X-ray diffraction, 17 pockets (best druggability 0.78). MolNFT v1…

PDB: 3R74
Type: protein
Length: 1,233 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ANTHRANILATE/PARA-aminobenzoate synthases component I
EC: 4.1.3.27
UniProt: Q396C7
Pockets: 17 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ANTHRANILATE/PARA-aminobenzoate synthases component I (EC 4.1.3.27)	protein	617	31% helix, 32% strand	Q396C7
B	ANTHRANILATE/PARA-aminobenzoate synthases component I (EC 4.1.3.27)	protein	616	29% helix, 31% strand	Q396C7

Pockets

17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	873	0.78	0.81	92	empty
2	970	0.77	0.80	87	empty
3	155	0.73	0.91	33	empty
4	314	0.72	0.85	35	empty
5	399	0.71	0.82	49	empty

Interfaces

1 interface between chains.

A–B · 3652 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

3R74 · Crystal structure of 2-amino-2-desoxyisochorismate synthase (ADIC) synthase PhzE from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q396C7
Elsewhere: RCSB PDB 3R74 · PDBe 3R74 · UniProt Q396C7

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