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Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase phze from burkholderia lata 383
Analyse Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3R74
- Type
- protein
- Length
- 1,233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ANTHRANILATE/PARA-aminobenzoate synthases component I
- EC
- 4.1.3.27
- UniProt
- Q396C7
- Pockets
- 17 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ANTHRANILATE/PARA-aminobenzoate synthases component I (EC 4.1.3.27) | protein | 617 | 31% helix, 32% strand | Q396C7 |
| B | ANTHRANILATE/PARA-aminobenzoate synthases component I (EC 4.1.3.27) | protein | 616 | 29% helix, 31% strand | Q396C7 |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 873 | 0.78 | 0.81 | 92 | empty |
| 2 | 970 | 0.77 | 0.80 | 87 | empty |
| 3 | 155 | 0.73 | 0.91 | 33 | empty |
| 4 | 314 | 0.72 | 0.85 | 35 | empty |
| 5 | 399 | 0.71 | 0.82 | 49 | empty |
Interfaces
1 interface between chains.
- A–B · 3652 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 3R74 · Crystal structure of 2-amino-2-desoxyisochorismate synthase (ADIC) synthase PhzE from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q396C7
- Elsewhere: RCSB PDB 3R74 · PDBe 3R74 · UniProt Q396C7
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