MolNFT v1 · #76627 · protein

The retinal specific CD147 IG0 domain: from molecular structure to biological activity

3QQN · Basigin: “The retinal specific CD147 IG0 domain: from molecular structure to biological activity”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #76627 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3QQN
Type: protein
Length: 233 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Basigin
UniProt: P35613
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Basigin	protein	117	6% helix, 50% strand	P35613
B	Basigin	protein	116	6% helix, 48% strand	P35613

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.52	0.78	28	empty
2	205	0.47	0.75	28	empty

Interfaces

1 interface between chains.

A–B · 826 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified, 2 disulfide (engineered, disulfide).

Compared structures

3QQN · The retinal specific CD147 Ig0 domain: from molecular structure to biological activity · the same entry in another collection · chain A against A, TM-score 1.00
P35613 · AlphaFold monomer V2.0 prediction for basigin (P35613) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35613
Elsewhere: RCSB PDB 3QQN · PDBe 3QQN · UniProt P35613

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