MolNFT v1 · #76463 · protein
Crystal structure of atrx add domain in free state
3QLN · Transcriptional regulator atrx: “Crystal structure of atrx add domain in free state”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.48). MolNFT v1 #76463 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3QLN
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator atrx
- EC
- 3.6.4.12
- UniProt
- P46100
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator atrx (EC 3.6.4.12) | protein | 123 | 32% helix, 13% strand | P46100 |
| B | Transcriptional regulator atrx (EC 3.6.4.12) | protein | 118 | 32% helix, 14% strand | P46100 |
Ligands and binding sites
- ZN · Zinc ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 143 | 0.48 | 0.78 | 23 | empty |
| 2 | 50 | 0.27 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 285 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46100
- Elsewhere: RCSB PDB 3QLN · PDBe 3QLN · UniProt P46100
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