MolNFT v1 · #76369 · protein
Crystal structure of PIWIL2 paz domain
3QIR · Piwi-like protein 2: “Crystal structure of PIWIL2 paz domain”. X-ray diffraction, 3 pockets (best druggability 0.54). MolNFT v1 #76369 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3QIR
- Type
- protein
- Length
- 436 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Piwi-like protein 2
- UniProt
- Q8TC59
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Piwi-like protein 2 | protein | 112 | 32% helix, 22% strand | Q8TC59 |
| B | Piwi-like protein 2 | protein | 104 | 35% helix, 27% strand | Q8TC59 |
| C | Piwi-like protein 2 | protein | 105 | 34% helix, 27% strand | Q8TC59 |
| D | Piwi-like protein 2 | protein | 115 | 29% helix, 27% strand | Q8TC59 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.54 | 0.75 | 31 | empty |
| 2 | 188 | 0.52 | 0.77 | 27 | empty |
| 3 | 231 | 0.48 | 0.74 | 28 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1162 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 722 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 674 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TC59
- Elsewhere: RCSB PDB 3QIR · PDBe 3QIR · UniProt Q8TC59
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