MolNFT v1 · #300350 · protein

AlphaFold monomer V2.0 prediction for piwi-like protein 2 (Q8TC59)

Q8TC59: “AlphaFold monomer V2.0 prediction for piwi-like protein 2 (Q8TC59)”. 9 pockets (best druggability 0.84). MolNFT v1 #300350 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q8TC59
Type: protein
Length: 973 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xEa58c7534E5701aA8370E0fAEb19b7e14653e69c
Molecule: Piwi-like protein 2
UniProt: Q8TC59
Pockets: 9 · best druggability 0.84

Structure

1 distinct chain · 25% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Piwi-like protein 2	protein	973	25% helix, 23% strand	Q8TC59

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1083	0.84	0.85	101	empty
2	378	0.65	0.79	45	empty
3	215	0.62	0.82	29	empty
4	187	0.52	0.78	28	empty
5	63	0.37	0.78	11	empty

Compared structures

3QIR · Crystal structure of PIWIL2 PAZ domain · an experimental structure of the same protein · chain A against D, TM-score 0.10
3QIR · Crystal structure of PIWIL2 paz domain · an experimental structure of the same protein · chain A against D, TM-score 0.10
3O7X · Crystal structure of human Hili PAZ domain · an experimental structure of the same protein · chain A against D, TM-score 0.10
3O7X · Crystal structure of human hili paz domain · an experimental structure of the same protein · chain A against D, TM-score 0.10

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TC59
Elsewhere: UniProt Q8TC59 · AlphaFold DB Q8TC59

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