MolNFT v1 · #76159 · protein

Crystal structure of FAF1 ubx domain in complex with P97/VCP N domain reveals the conserved fcisp touch-turn motif of ubx domain suffering conformational change

3QC8 · Transitional endoplasmic reticulum ATPase: “Crystal structure of FAF1 ubx domain in complex with P97/VCP N domain reveals the conserved fcisp touch-turn…”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #76159 on…

PDB: 3QC8
Type: protein
Length: 250 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transitional endoplasmic reticulum ATPase; Fas-associated factor 1
UniProt: P55072, Q9UNN5
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transitional endoplasmic reticulum ATPase	protein	170	16% helix, 41% strand	P55072
B	Fas-associated factor 1	protein	80	15% helix, 39% strand	Q9UNN5

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.35	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 905 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3QC8 · Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The… · the same entry in another collection · chain A against A, TM-score 1.00
Q9UNN5 · AlphaFold monomer V2.0 prediction for fas-associated factor 1 (Q9UNN5) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55072
Every structure of UniProt Q9UNN5
Elsewhere: RCSB PDB 3QC8 · PDBe 3QC8 · UniProt P55072 · UniProt Q9UNN5

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